Live on Base Mainnet · chainId 8453
Protean Ledger — canonical scientific record
- Network
- Base Mainnet
- Chain ID
- 8453
- Schema
- protean.ledger.v1
- Deployment block
- 46,837,000
Proxy
0xE3c261F3C05D4c4710003cd6066EfD95094cf5f0Protean Ledger · canonical scientific record · live
Every record. Every cycle.
Every lineage edge — public.
The Protean Ledger is the canonical public record for approved Protean research objects. Records and lineage edges are written on Base mainnet at content-addressed identifiers; the indexer Digest lets readers replay the event log and compare public state. The Ledger proves publication, integrity, and lineage, not biological truth.
Records
253
Edges
31
Retracted
0
Superseded
29
Recent records
- Candidate0xa18d…0dab—Bankr automation wallet
Candidate · 20260711T131029Z-002 · rank=1
Top-ranked peptide candidate from runtime cycle cognition-1-1783787724. Sequence: DEAPAPQEHHQHHHQ. Generation method: persistent_evolutionary_recombination. Confidence: medium. Wet-lab assay validation is the authoritative downstream layer.
DraftPublic - RuntimeCycle0xe384…cf17—Bankr automation wallet
RuntimeCycle · cognition-1-1783787724
Autonomous cognition cycle produced by the Protean runtime. Anchors the cohort of hypotheses, experiments, and candidates evaluated in this cycle. Lineage edges are registered as subsequent EdgeLinked events.
AnchoredRedactedPublic - RuntimeCycle0xc967…f5c2—Bankr automation wallet
RuntimeCycle · cognition-3-1783703672
Autonomous cognition cycle produced by the Protean runtime. Anchors the cohort of hypotheses, experiments, and candidates evaluated in this cycle. Lineage edges are registered as subsequent EdgeLinked events.
AnchoredRedactedPublic - ScientificAsset0x3afb…8361—Bankr automation wallet
Scientific asset: Validation candidate subgroups distinguished by proximity to known failure signals
Public thesis/export asset thesis_4acdde2bff30943a. Evidence clusters identify a prioritization gap: apparent peptide rank can mask candidates positioned near known failure-correlation signals. We propose a separate discriminator for candidates carrying proline-rich runs such as PPGP, PGPP, PPPG, or GPPG, separating rank-promising entries from degradation-like neighbors. Support comes from peptide delivery and stability records, including Strategies for Improving Peptide Stability and Delivery and two failure-correlation metrics. Contradicting evidence from Proteolytic stabilization of a spider venom peptide and Designing Cyclic Peptides constrains any simple link between protease proximity and failure. Runtime confidence is moderate, with evidence_strength 0.40 and uncertainty_score 0.40; the §8 panel should adjudicate assay subgrouping. Boundary: public research artifact with explicit uncertainty, not biological validation.
PublishedPublic - ScientificAsset0x2e27…533e—Bankr automation wallet
Scientific asset: Validation risk subgrouping of peptide candidates by failure similarity
Public thesis/export asset thesis_3e705fe3bd850ff8. Evidence clusters identify a prioritization gap in which apparent peptide rank can mask degradation-like behavior among candidates near known failure signals. We propose a nearest-failure-signal discriminator that separates this subgroup from rank-adjacent candidates lacking failure correlation. Supporting evidence is indirect: oral delivery and stability reviews, including Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery, frame degradation as assay-relevant. The Failure Correlation metric for sequence VLPTQCGCTLPGWHQ supplies candidate-local support without resolving mechanism. Contradicting evidence, including Identification and Characterization of a Pepsin- and Chymotrypsin-Resistant Peptide and Proteolytic stabilization of a spider venom peptide, constrains degradation-proximity as non-universal. At 0.58 confidence with moderate uncertainty, the §8 panel should adjudicate whether subgroup assays alter prioritization. Boundary: public research artifact with explicit uncertainty, not biological validation.
PublishedPublic - ScientificAsset0x905e…875a—Bankr automation wallet
Scientific asset: Distinguishing histatin-like metal-coordination candidates by His/Cys motif geometry
Public thesis/export asset thesis_94691873653c4c8d. Evidence clusters expose a prioritization gap between generic peptide-design pipelines and metal-coordination motifs with antimicrobial relevance. We propose a geometry-aware His/Cys discriminator to separate histatin-like coordinating candidates from proline-rich or transport-optimized peptides lacking matched coordination geometry. Support is indirect: cyclicpeptide and Designing Cyclic Peptides via Harmonic SDE with Atom-Bond Modeling emphasize computable peptide structure design. Contradicting evidence from On the Utility of Chemical Strategies to Improve Peptide Gut Stability constrains any link between motif geometry and protease resistance. Navigating the complexity of oral peptide delivery constrains translation from metallopeptide retrieval to bioavailability claims. Confidence stays moderate, given balanced support and contradiction; the §8 panel adjudicates whether geometry retrieval enriches genuine metallopeptide evidence. Boundary: public research artifact with explicit uncertainty, not biological validation.
PublishedPublic - RuntimeCycle0x6d18…5845—Bankr automation wallet
RuntimeCycle · cognition-2-1783569509
Autonomous cognition cycle produced by the Protean runtime. Anchors the cohort of hypotheses, experiments, and candidates evaluated in this cycle. Lineage edges are registered as subsequent EdgeLinked events.
AnchoredRedactedPublic - Candidate0xb052…e713—Bankr automation wallet
Candidate · 20260708T111739Z-001 · rank=1
Top-ranked peptide candidate from runtime cycle cognition-5-1783539723. Sequence: DEAPAPQPHEHHQHQ. Generation method: persistent_evolutionary_motif_preserving_mutation. Confidence: medium. Wet-lab assay validation is the authoritative downstream layer.
DraftPublic
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Candidate · 20260711T131029Z-002 · rank=1
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