Summary
Public thesis/export asset thesis_94691873653c4c8d. Evidence clusters expose a prioritization gap between generic peptide-design pipelines and metal-coordination motifs with antimicrobial relevance. We propose a geometry-aware His/Cys discriminator to separate histatin-like coordinating candidates from proline-rich or transport-optimized peptides lacking matched coordination geometry. Support is indirect: cyclicpeptide and Designing Cyclic Peptides via Harmonic SDE with Atom-Bond Modeling emphasize computable peptide structure design. Contradicting evidence from On the Utility of Chemical Strategies to Improve Peptide Gut Stability constrains any link between motif geometry and protease resistance. Navigating the complexity of oral peptide delivery constrains translation from metallopeptide retrieval to bioavailability claims. Confidence stays moderate, given balanced support and contradiction; the §8 panel adjudicates whether geometry retrieval enriches genuine metallopeptide evidence. Boundary: public research artifact with explicit uncertainty, not biological validation.