Summary
Public thesis/export asset thesis_3e705fe3bd850ff8. Evidence clusters identify a prioritization gap in which apparent peptide rank can mask degradation-like behavior among candidates near known failure signals. We propose a nearest-failure-signal discriminator that separates this subgroup from rank-adjacent candidates lacking failure correlation. Supporting evidence is indirect: oral delivery and stability reviews, including Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery, frame degradation as assay-relevant. The Failure Correlation metric for sequence VLPTQCGCTLPGWHQ supplies candidate-local support without resolving mechanism. Contradicting evidence, including Identification and Characterization of a Pepsin- and Chymotrypsin-Resistant Peptide and Proteolytic stabilization of a spider venom peptide, constrains degradation-proximity as non-universal. At 0.58 confidence with moderate uncertainty, the §8 panel should adjudicate whether subgroup assays alter prioritization. Boundary: public research artifact with explicit uncertainty, not biological validation.