Summary
Public thesis/export asset thesis_4acdde2bff30943a. Evidence clusters identify a prioritization gap: apparent peptide rank can mask candidates positioned near known failure-correlation signals. We propose a separate discriminator for candidates carrying proline-rich runs such as PPGP, PGPP, PPPG, or GPPG, separating rank-promising entries from degradation-like neighbors. Support comes from peptide delivery and stability records, including Strategies for Improving Peptide Stability and Delivery and two failure-correlation metrics. Contradicting evidence from Proteolytic stabilization of a spider venom peptide and Designing Cyclic Peptides constrains any simple link between protease proximity and failure. Runtime confidence is moderate, with evidence_strength 0.40 and uncertainty_score 0.40; the §8 panel should adjudicate assay subgrouping. Boundary: public research artifact with explicit uncertainty, not biological validation.