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Protean

Candidate 20260613T025625Z-035

MGGEVLPQQPVQSAQEQH

Why this candidate advanced

Advanced for computational review because it showed low exposed hydrophobic and ordered in the immune modulator campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable immune modulator activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…
Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision
promote for review
pLDDT
58.9
Compactness
0.511
Exposed hydrophobic
0.196
Disulfide feasible
no
Structural novelty
0.000
Fold family
fold_cluster_000
Route
esmfold2_sidecar
Predicted structure source
ESMFold2 sidecar

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_3116f73ffa611ff5 (18 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the immune modulator campaign.

Structural prior signals: low exposed hydrophobic, ordered. pLDDT 58.89; compactness 0.511; exposed-hydrophobic 0.1963.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition
MGGEVLPQQPVQSAQEQH
18 aa
immune_modulator
hydrophobic28%
polar33%
positive6%
negative11%
aromatic0%
C/P/G22%
no sequence flags
Fold evidence
very high 0%
confident 0%
low 100%
very low 0%
helix33%
sheet53%
coil13%
mean pLDDT
58.9
min pLDDT
53.0
compactness
0.511
exposed hydrophobic
0.196
radius of gyration
11.503
novelty
0.000
Computational decision
promote for review

Triage label: favored

Evidence signatures

low_exposed_hydrophobic, ordered

ESMFold2 comparison
esmfold2-fast-2026-05 · folded
pLDDT 58.89 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties
Computed from sequence (ProtParam-style). Computational, not biological proof.
Length
18 aa
Mol. weight
1.96 kDa
Net charge (pH 7.4)
-1.95
Isoelectric pt (pI)
4.25
GRAVY
-0.92
Aromaticity
0%
Per-residue model confidence (pLDDT)
ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile
Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.
4.50-4.5hydrophilic ↓ / hydrophobic ↑ · window 5
Sequence (colored by hydrophobicity)
Each residue shaded by Kyte–Doolittle value; hover for position + score.
M
G
G
E
V
5
L
P
Q
Q
P
10
V
Q
S
A
Q
15
E
Q
H

Provenance

provenance_hash: sha256:3116f73ffa611ff55dfeebfd4a0278fc944a219aa0d5ce4f31580bfcfdf71f1e
pdb_sha256: sha256:76691e060b38251ece47f304b3b0f3fdf5737d9deb7265a2ec345b62dce7e9d7
campaign: immune_modulator
ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity