Candidate 20260612T222653Z-036

MGGEVLPQQPVQSGQEQH

Why this candidate advanced

Advanced for computational review because it showed low exposed hydrophobic and ordered in the immune modulator campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable immune modulator activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…

Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision

promote for review

pLDDT

62.6

Compactness

0.505

Exposed hydrophobic

0.174

Disulfide feasible

Structural novelty

0.000

Fold family

fold_cluster_000

Route

esmfold2_sidecar

Predicted structure source

ESMFold2 sidecar

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_f07502d9c3ae06de (18 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the immune modulator campaign.

Structural prior signals: low exposed hydrophobic, ordered. pLDDT 62.56; compactness 0.5049; exposed-hydrophobic 0.1741.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition

MGGEVLPQQPVQSGQEQH

18 aa

immune_modulator

hydrophobic22%

polar33%

positive6%

negative11%

aromatic0%

C/P/G28%

no sequence flags

Fold evidence

very high 0%

confident 11%

low 89%

very low 0%

helix13%

sheet53%

coil33%

mean pLDDT

62.6

min pLDDT

56.0

compactness

0.505

exposed hydrophobic

0.174

radius of gyration

11.641

novelty

0.000

Computational decision

promote for review

Triage label: favored

Evidence signatures

low_exposed_hydrophobic, ordered

ESMFold2 comparison

esmfold2-fast-2026-05 · folded

pLDDT 62.56 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties

Computed from sequence (ProtParam-style). Computational, not biological proof.

Length

18 aa

Mol. weight

1.95 kDa

Net charge (pH 7.4)

-1.95

Isoelectric pt (pI)

4.25

GRAVY

-1.04

Aromaticity

Per-residue model confidence (pLDDT)

ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile

Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.

Sequence (colored by hydrophobicity)

Each residue shaded by Kyte–Doolittle value; hover for position + score.

Provenance

provenance_hash: sha256:f07502d9c3ae06de20cd2539dbfe88ad2fb34c6f56581da9c8d1851ee924c475

pdb_sha256: sha256:dbeeb20ab7d71cb2c5280b4adfbb6439d0b44172ee7ade0a2b3ecc96170597e6

campaign: immune_modulator

ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity