Candidate 20260613T025625Z-030

FPDNGDQQQEMGKH

Why this candidate advanced

Advanced for computational review because it showed compact fold, low exposed hydrophobic and ordered in the immune modulator campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable immune modulator activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…

Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision

promote for review

pLDDT

53.2

Compactness

0.865

Exposed hydrophobic

0.075

Disulfide feasible

Structural novelty

0.000

Fold family

fold_cluster_000

Route

esmfold2_sidecar

Predicted structure source

ESMFold2 sidecar

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_9c6e1074d3d23554 (14 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the immune modulator campaign.

Structural prior signals: compact fold, low exposed hydrophobic, ordered. pLDDT 53.21; compactness 0.865; exposed-hydrophobic 0.0746.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition

FPDNGDQQQEMGKH

14 aa

immune_modulator

hydrophobic14%

polar29%

positive14%

negative21%

aromatic7%

C/P/G21%

deamidation motif

Fold evidence

very high 0%

confident 0%

low 93%

very low 7%

helix55%

sheet27%

coil18%

mean pLDDT

53.2

min pLDDT

49.0

compactness

0.865

exposed hydrophobic

0.075

radius of gyration

6.239

novelty

0.000

Computational decision

promote for review

Triage label: favored

Evidence signatures

compact_fold, low_exposed_hydrophobic, ordered

ESMFold2 comparison

esmfold2-fast-2026-05 · folded

pLDDT 53.21 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties

Computed from sequence (ProtParam-style). Computational, not biological proof.

Length

14 aa

Mol. weight

1.63 kDa

Net charge (pH 7.4)

-1.95

Isoelectric pt (pI)

4.37

GRAVY

-2.09

Aromaticity

Per-residue model confidence (pLDDT)

ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile

Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.

Sequence (colored by hydrophobicity)

Each residue shaded by Kyte–Doolittle value; hover for position + score.

Provenance

provenance_hash: sha256:9c6e1074d3d23554344a48a47a813bdc179e18b75764ac6a3da6a4c2b798c56e

pdb_sha256: sha256:8dd76f48923ceb56eeceb9ed289b782eb2034a10a625ee835b3147140ddf4a26

campaign: immune_modulator

ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity