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Protean

Candidate 20260612T222653Z-010

ILPQEMGGDQQQEMGKH

Why this candidate advanced

Advanced for computational review because it showed compact fold, low exposed hydrophobic and ordered in the immune modulator campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable immune modulator activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…
Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision
promote for review
pLDDT
52.4
Compactness
0.843
Exposed hydrophobic
0.158
Disulfide feasible
no
Structural novelty
0.000
Fold family
fold_cluster_000
Route
esmfold2_sidecar
Predicted structure source
ESMFold2 sidecar

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_314b5961eda19d8a (17 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the immune modulator campaign.

Structural prior signals: compact fold, low exposed hydrophobic, ordered. pLDDT 52.41; compactness 0.8428; exposed-hydrophobic 0.1582.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition
ILPQEMGGDQQQEMGKH
17 aa
immune_modulator
hydrophobic24%
polar24%
positive12%
negative18%
aromatic0%
C/P/G24%
no sequence flags
Fold evidence
very high 0%
confident 0%
low 94%
very low 6%
helix50%
sheet14%
coil36%
mean pLDDT
52.4
min pLDDT
49.0
compactness
0.843
exposed hydrophobic
0.158
radius of gyration
6.840
novelty
0.000
Computational decision
promote for review

Triage label: favored

Evidence signatures

compact_fold, low_exposed_hydrophobic, ordered

ESMFold2 comparison
esmfold2-fast-2026-05 · folded
pLDDT 52.41 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties
Computed from sequence (ProtParam-style). Computational, not biological proof.
Length
17 aa
Mol. weight
1.93 kDa
Net charge (pH 7.4)
-1.95
Isoelectric pt (pI)
4.42
GRAVY
-1.31
Aromaticity
0%
Per-residue model confidence (pLDDT)
ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile
Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.
4.50-4.5hydrophilic ↓ / hydrophobic ↑ · window 5
Sequence (colored by hydrophobicity)
Each residue shaded by Kyte–Doolittle value; hover for position + score.
I
L
P
Q
E
5
M
G
G
D
Q
10
Q
Q
E
M
G
15
K
H

Provenance

provenance_hash: sha256:314b5961eda19d8a688dd97f0499614199d7fe1af7a41fee543264bc31295842
pdb_sha256: sha256:876bf8a1826130f5f5c9ac7747b5672c9ff99980ac9801a03f3f086817129594
campaign: immune_modulator
ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity