Candidate 20260613T025625Z-022

WPQEMGTSWPPNQCQ

Why this candidate advanced

Advanced for computational review because it showed compact fold, low exposed hydrophobic and ordered in the immune modulator campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable immune modulator activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…

Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision

promote for review

pLDDT

52.7

Compactness

0.973

Exposed hydrophobic

0.002

Disulfide feasible

Structural novelty

0.000

Fold family

fold_cluster_000

Route

esmfold2_sidecar

Predicted structure source

ESMFold2 sidecar

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_73ea8acb327a75d5 (15 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the immune modulator campaign.

Structural prior signals: compact fold, low exposed hydrophobic, ordered. pLDDT 52.67; compactness 0.9731; exposed-hydrophobic 0.0015.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition

WPQEMGTSWPPNQCQ

15 aa

immune_modulator

hydrophobic20%

polar47%

positive0%

negative7%

aromatic13%

C/P/G33%

odd cysteine

Fold evidence

very high 0%

confident 0%

low 87%

very low 13%

helix33%

sheet42%

coil25%

mean pLDDT

52.7

min pLDDT

49.0

compactness

0.973

exposed hydrophobic

0.002

radius of gyration

5.677

novelty

0.000

Computational decision

promote for review

Triage label: favored

Evidence signatures

compact_fold, low_exposed_hydrophobic, ordered

ESMFold2 comparison

esmfold2-fast-2026-05 · folded

pLDDT 52.67 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties

Computed from sequence (ProtParam-style). Computational, not biological proof.

Length

15 aa

Mol. weight

1.79 kDa

Net charge (pH 7.4)

-1.13

Isoelectric pt (pI)

3.85

GRAVY

-1.44

Aromaticity

13%

Per-residue model confidence (pLDDT)

ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile

Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.

Sequence (colored by hydrophobicity)

Each residue shaded by Kyte–Doolittle value; hover for position + score.

Provenance

provenance_hash: sha256:73ea8acb327a75d5fd69bc215d460f82ac8ea47314a2b6dbb6c4d2d086878d70

pdb_sha256: sha256:893c7c52e4076e328cc0c76d198f192c22c1d44b2c0241b50b13538a5828cef3

campaign: immune_modulator

ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity