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Protean

Candidate 20260612T222653Z-032

WPQEMGTSWPPNQWQ

Why this candidate advanced

Advanced for computational review because it showed compact fold and low exposed hydrophobic in the immune modulator campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable immune modulator activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…
Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision
promote for review
pLDDT
50.5
Compactness
0.790
Exposed hydrophobic
0.000
Disulfide feasible
no
Structural novelty
0.000
Fold family
fold_cluster_000
Route
esmfold2_sidecar
Predicted structure source
ESMFold2 sidecar

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_5acc7d739c57b32e (15 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the immune modulator campaign.

Structural prior signals: compact fold, low exposed hydrophobic. pLDDT 50.53; compactness 0.7903; exposed-hydrophobic 0.0.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition
WPQEMGTSWPPNQWQ
15 aa
immune_modulator
hydrophobic27%
polar40%
positive0%
negative7%
aromatic20%
C/P/G27%
no sequence flags
Fold evidence
very high 0%
confident 0%
low 67%
very low 33%
helix33%
sheet25%
coil42%
mean pLDDT
50.5
min pLDDT
45.0
compactness
0.790
exposed hydrophobic
0.000
radius of gyration
6.990
novelty
0.000
Computational decision
promote for review

Triage label: favored

Evidence signatures

compact_fold, low_exposed_hydrophobic

ESMFold2 comparison
esmfold2-fast-2026-05 · folded
pLDDT 50.53 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties
Computed from sequence (ProtParam-style). Computational, not biological proof.
Length
15 aa
Mol. weight
1.87 kDa
Net charge (pH 7.4)
-1.06
Isoelectric pt (pI)
3.85
GRAVY
-1.67
Aromaticity
20%
Per-residue model confidence (pLDDT)
ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile
Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.
4.50-4.5hydrophilic ↓ / hydrophobic ↑ · window 5
Sequence (colored by hydrophobicity)
Each residue shaded by Kyte–Doolittle value; hover for position + score.
W
P
Q
E
M
5
G
T
S
W
P
10
P
N
Q
W
Q
15

Provenance

provenance_hash: sha256:5acc7d739c57b32e4038cbaa39308b5452ba965985f8d8b11142eb1a7592b8ca
pdb_sha256: sha256:77f144d2ea7a6550d688842d74291760a49c9236ce49d9dc45283f3946592c87
campaign: immune_modulator
ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity