Candidate cycle-20260526T020837Z-0…

KPADSQHHNQNQRHHQW

Why this candidate advanced

Advanced for computational review because it showed low exposed hydrophobic and ordered in the phenotype first unknown target campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable phenotype first unknown target activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…

Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision

promote for review

pLDDT

61.4

Compactness

0.463

Exposed hydrophobic

0.012

Disulfide feasible

Structural novelty

1.000

Fold family

fold_cluster_000

Route

remote_esmatlas

Predicted structure source

ESMFold prediction

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_e10cfbcc29801e8d (17 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the phenotype-first (unknown target) campaign.

Structural prior signals: low exposed hydrophobic, ordered. pLDDT 61.35; compactness 0.4626; exposed-hydrophobic 0.0118.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 1.000; fold family fold_cluster_000 (family size 10). No structural archive match available; novelty by feature-vector fallback.

Sequence brief

Residue composition

KPADSQHHNQNQRHHQW

17 aa

phenotype_first_unknown_target

hydrophobic12%

polar41%

positive35%

negative6%

aromatic6%

C/P/G6%

no sequence flags

Fold evidence

very high 0%

confident 0%

low 88%

very low 12%

helix7%

sheet50%

coil43%

mean pLDDT

52.8

min pLDDT

45.0

compactness

0.463

exposed hydrophobic

0.012

radius of gyration

12.462

novelty

1.000

Computational decision

promote for review

Triage label: favored

Evidence signatures

low_exposed_hydrophobic, ordered

ESMFold2 comparison

esmfold2-fast-2026-05 · folded

pLDDT 52.82 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties

Computed from sequence (ProtParam-style). Computational, not biological proof.

Length

17 aa

Mol. weight

2.15 kDa

Net charge (pH 7.4)

+1.39

Isoelectric pt (pI)

9.70

GRAVY

-2.78

Aromaticity

Per-residue model confidence (pLDDT)

ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile

Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.

Sequence (colored by hydrophobicity)

Each residue shaded by Kyte–Doolittle value; hover for position + score.

Provenance

provenance_hash: sha256:e10cfbcc29801e8d7a2d1cbda5ac4950b5de81b93a55f60df809acb7824f8a01

pdb_sha256: sha256:2c2905e5d5a26170b33e9c8564dadecb97868a39a5aca73f7353606238a8f550

campaign: phenotype_first_unknown_target

ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity