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Protean

Candidate cycle-20260526T020837Z-0…

DCDQTNWPCGGQQHCDKA

Why this candidate advanced

Advanced for computational review because it showed compact fold in the phenotype first unknown target campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is hold for review.

Next experimental question

Does this sequence show measurable phenotype first unknown target activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…
Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision
hold for review
fold confidence (proxy)
0.44
Compactness
0.849
Exposed hydrophobic
0.357
Disulfide feasible
no
Structural novelty
0.000
Fold family
fold_cluster_000
Route
deterministic_proxy
Predicted structure source
sequence proxy

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_dd9ebccbcb6f52c0 (18 aa) was advanced by Protean's structure-intelligence rerank as a hold for review within the phenotype-first (unknown target) campaign.

Structural prior signals: compact fold. fold-confidence proxy 0.4408; compactness 0.8494; exposed-hydrophobic 0.3567.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition
DCDQTNWPCGGQQHCDKA
18 aa
phenotype_first_unknown_target
hydrophobic11%
polar44%
positive11%
negative17%
aromatic6%
C/P/G33%
odd cysteine
Fold evidence
very high 0%
confident 0%
low 39%
very low 61%
helix33%
sheet0%
coil67%
mean pLDDT
48.1
min pLDDT
41.0
compactness
0.849
exposed hydrophobic
0.357
radius of gyration
6.920
proxy novelty
0.000
Computational decision
hold for review

Triage label: neutral

Evidence signatures

compact_fold

ESMFold2 comparison
esmfold2-fast-2026-05 · folded
pLDDT 48.11 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties
Computed from sequence (ProtParam-style). Computational, not biological proof.
Length
18 aa
Mol. weight
2.01 kDa
Net charge (pH 7.4)
-2.17
Isoelectric pt (pI)
4.31
GRAVY
-1.46
Aromaticity
6%
Per-residue model confidence (pLDDT)
ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile
Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.
4.50-4.5hydrophilic ↓ / hydrophobic ↑ · window 5
Sequence (colored by hydrophobicity)
Each residue shaded by Kyte–Doolittle value; hover for position + score.
D
C
D
Q
T
5
N
W
P
C
G
10
G
Q
Q
H
C
15
D
K
A

Provenance

provenance_hash: sha256:dd9ebccbcb6f52c027e055f955b0906a36acda8b97135211482fe797a708e0cc
pdb_sha256: 6aed37fea64913c745b852cc9458a84e2713da1d8286182713b27d73ff3caa79
campaign: phenotype_first_unknown_target
ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity