Candidate cycle-20260526T020837Z-0…
HQMAQHCDDCDQFPTDCG
Why this candidate advanced
Advanced for computational review because it showed compact fold, low exposed hydrophobic and ordered in the phenotype first unknown target campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.
Next experimental question
Does this sequence show measurable phenotype first unknown target activity, target engagement, or useful stability under controlled assay conditions?
Structure
Structure Intelligence
Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.
Research narrative
This is a computational prioritization result, not evidence of biological activity. Candidate struct_73519d94d50c71cb (18 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the phenotype-first (unknown target) campaign.
Structural prior signals: compact fold, low exposed hydrophobic, ordered. pLDDT 65.89; compactness 0.7485; exposed-hydrophobic 0.0802.
Disulfide assessment: no feasible disulfide pattern detected.
Novelty: structural-novelty score 1.000; fold family fold_cluster_000 (family size 10). No structural archive match available; novelty by feature-vector fallback.
Sequence brief
Triage label: favored
compact_fold, low_exposed_hydrophobic, ordered
Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.
Sequence & model analysis
No per-residue confidence available — a folded coordinate file has not been published for this candidate.
Provenance
computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity