Candidate cycle-20260526T020837Z-0…

GHQMQHHCDDSQPTDCWP

Why this candidate advanced

Advanced for computational review because it showed compact fold, low exposed hydrophobic and ordered in the phenotype first unknown target campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable phenotype first unknown target activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…

Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision

promote for review

pLDDT

57.1

Compactness

0.701

Exposed hydrophobic

0.012

Disulfide feasible

yes (2 Cys)

Structural novelty

1.000

Fold family

fold_cluster_000

Route

remote_esmatlas

Predicted structure source

ESMFold prediction

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_67452baa95461577 (18 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the phenotype-first (unknown target) campaign.

Structural prior signals: compact fold, low exposed hydrophobic, ordered. pLDDT 57.11; compactness 0.7009; exposed-hydrophobic 0.0123.

Disulfide assessment: 2 cysteines form a parity-even, feasible disulfide pattern (1 max pair(s)).

Novelty: structural-novelty score 1.000; fold family fold_cluster_000 (family size 10). No structural archive match available; novelty by feature-vector fallback.

Sequence brief

Residue composition

GHQMQHHCDDSQPTDCWP

18 aa

phenotype_first_unknown_target

hydrophobic11%

polar39%

positive17%

negative17%

aromatic6%

C/P/G28%

no sequence flags

Fold evidence

very high 0%

confident 0%

low 78%

very low 22%

helix13%

sheet80%

coil7%

mean pLDDT

53.6

min pLDDT

45.0

compactness

0.701

exposed hydrophobic

0.012

radius of gyration

8.386

novelty

1.000

Computational decision

promote for review

Triage label: favored

Evidence signatures

compact_fold, low_exposed_hydrophobic, ordered

ESMFold2 comparison

esmfold2-fast-2026-05 · folded

pLDDT 53.61 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties

Computed from sequence (ProtParam-style). Computational, not biological proof.

Length

18 aa

Mol. weight

2.12 kDa

Net charge (pH 7.4)

-2.87

Isoelectric pt (pI)

5.23

GRAVY

-1.65

Aromaticity

Per-residue model confidence (pLDDT)

ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile

Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.

Sequence (colored by hydrophobicity)

Each residue shaded by Kyte–Doolittle value; hover for position + score.

Provenance

provenance_hash: sha256:67452baa9546157708177f4e19870501ca896aa53613433dfca41a621c6ec63c

pdb_sha256: sha256:4e2ac64cfc11fb56cf6d553d7d6e56cce0b698b02953c7ec08aa6038240739b5

campaign: phenotype_first_unknown_target

ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity