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Protean

Candidate 20260612T222653Z-011

RPEMGGERAQQPPRANT

Why this candidate advanced

Advanced for computational review because it showed compact fold, low exposed hydrophobic and ordered in the phenotype first unknown target campaign. This is a structural-prior signal only, not evidence of activity. The current computational decision is promote for review.

Next experimental question

Does this sequence show measurable phenotype first unknown target activity, target engagement, or useful stability under controlled assay conditions?

Structure

Loading structure…
Predicted structure (ESMFold). Computational prediction — not an experimental structure and not biological proof.

Structure Intelligence

Computational decision
promote for review
pLDDT
53.9
Compactness
0.682
Exposed hydrophobic
0.072
Disulfide feasible
no
Structural novelty
0.000
Fold family
fold_cluster_000
Route
esmfold2_sidecar
Predicted structure source
ESMFold2 sidecar

Computational structural priors only. ESMFold/ESMFold2 predictions are not experimental structures or evidence of activity.

Research narrative

This is a computational prioritization result, not evidence of biological activity. Candidate struct_a4022b041e7ea43a (17 aa) was advanced by Protean's structure-intelligence rerank as a promote for review within the phenotype-first (unknown target) campaign.

Structural prior signals: compact fold, low exposed hydrophobic, ordered. pLDDT 53.94; compactness 0.6824; exposed-hydrophobic 0.0719.

Disulfide assessment: no feasible disulfide pattern detected.

Novelty: structural-novelty score 0.000; fold family fold_cluster_000 (family size 10). Nearest archived fold at structural distance 0.000.

Sequence brief

Residue composition
RPEMGGERAQQPPRANT
17 aa
phenotype_first_unknown_target
hydrophobic18%
polar24%
positive18%
negative12%
aromatic0%
C/P/G29%
deamidation motif
Fold evidence
very high 0%
confident 0%
low 88%
very low 12%
helix50%
sheet29%
coil21%
mean pLDDT
53.9
min pLDDT
48.0
compactness
0.682
exposed hydrophobic
0.072
radius of gyration
8.448
novelty
0.000
Computational decision
promote for review

Triage label: favored

Evidence signatures

compact_fold, low_exposed_hydrophobic, ordered

ESMFold2 comparison
esmfold2-fast-2026-05 · folded
pLDDT 53.94 · pTM — · iPTM —

Sequence and structure signals are computational triage evidence. They do not establish activity, binding, stability, safety, or wet-lab readiness.

Sequence & model analysis

Physicochemical properties
Computed from sequence (ProtParam-style). Computational, not biological proof.
Length
17 aa
Mol. weight
1.90 kDa
Net charge (pH 7.4)
+0.94
Isoelectric pt (pI)
10.31
GRAVY
-1.87
Aromaticity
0%
Per-residue model confidence (pLDDT)
ESMFold per-residue confidence from the folded model (0–100).

No per-residue confidence available — a folded coordinate file has not been published for this candidate.

Hydropathy profile
Kyte–Doolittle windowed hydropathy. Positive = hydrophobic, negative = hydrophilic.
4.50-4.5hydrophilic ↓ / hydrophobic ↑ · window 5
Sequence (colored by hydrophobicity)
Each residue shaded by Kyte–Doolittle value; hover for position + score.
R
P
E
M
G
5
G
E
R
A
Q
10
Q
P
P
R
A
15
N
T

Provenance

provenance_hash: sha256:a4022b041e7ea43ab72e354f75dff8bbbafcf6cbe4d776a8bdffc82552e9e7a6
pdb_sha256: sha256:bc0a5b13cee5b7276e422876357a1797b89afd569a908f73eec5b7da03601c98
campaign: phenotype_first_unknown_target
ledger_record: not attested

computational structural prior; ESMFold/proxy prediction; not an experimental structure and not biological proof of fold, binding, stability, or activity