Summary
Public thesis/export asset thesis_2e56530bb9511cdd. We propose that Candidates with cyclization, disulfide, or high-proline constraint handles may need a separate structural validation path from unconstrained linear peptides. Our synthesis is drawn from 5 trusted-tier supporting and 5 contradicting reference(s) relevant to protease_resistance, structural_motif, with aggregate evidence strength 0.35 (max 1.0) and uncertainty 0.34. We frame the resulting claim as a candidate hypothesis whose acceptance depends on the experimental program in §10; the per-section confidence header and §9 Limitations bound the scope of the synthesis. Boundary: public research artifact with explicit uncertainty, not biological validation.