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Live on Base Mainnet · chainId 8453

Protean Ledger — canonical scientific record

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Network
Base Mainnet
Chain ID
8453
Schema
protean.ledger.v1
Deployment block
46,837,000

Proxy

0xE3c261F3C05D4c4710003cd6066EfD95094cf5f0
ScientificAssetPublishedPublic—0x57bb…deec

Scientific asset: Separating constrained from linear peptide candidates by conformational constraint handles

Author Protean Labs2026-06-03T05:20:06ZSigned by 0x074a…33de[Bankr automation wallet]

Stored on Base mainnet · chainId 8453

This record lives on the ProteanLedger UUPS proxy at 0xE3c261F3…94cf5f0. The chain is the source of truth — the explorer is a read-only lens.

Read contract on Basescan Download ABI
Network
Base mainnet
Block timestamp
re-indexing — refresh shortly
Recorded by
0x074a…33de[Bankr automation wallet]
Record ID
0x57bb604c…a6deec
Registration transaction
d6c14fc993…5215353cview on Basescan ↗
Block
#47,889,784view on Basescan ↗

Verify this record yourself

Four commands. Two terminals. No login. No wallet. No trust in Protean Labs required.

1. Read the record from chain

cast call 0xE3c261F3C05D4c4710003cd6066EfD95094cf5f0 \
  "getRecord(bytes32)" \
  0x57bb604c573629dabf9e252a3ae975eb3a09215c903ce8acb97985979fa6deec \
  --rpc-url https://mainnet.base.org

2. Inspect via the indexer JSON API

curl -s https://www.protean.sh/ledger/api/v1/records/0x57bb604c573629dabf9e252a3ae975eb3a09215c903ce8acb97985979fa6deec | jq

3. Reproduce the canonical state digest from genesis

curl -sL https://raw.githubusercontent.com/proteanlabs1/ledger-mirror/main/scripts/index_ledger_from_genesis.py -o index.py
python3 index.py --rpc https://mainnet.base.org \
  --proxy 0xE3c261F3C05D4c4710003cd6066EfD95094cf5f0 \
  --db protean.db --from-block 46837000 --once
python3 index.py --digest-only --db protean.db
# Compare against https://www.protean.sh/ledger/api/v1/indexer/digest

4. Confirm published indexer digest

curl -s https://www.protean.sh/ledger/api/v1/indexer/digest | jq '.digest, .record_count, .last_block'

Verification

What we can attest to from indexer state. Replay-artifact + content-digest verification you run yourself — see the verify page for copy-pasteable shell snippets and the public mirror for the canonical reproducibility script.

  1. 01.Record exists on chain (read via indexer)Pass
  2. 02.Indexer captured RecordContentEmitted (content rendered above)Pass
  3. 03.Replay pointer is an external scheme — reader verifies via the cited URL/CID/txPass
  4. 04.Lineage edges loaded from the indexer; walk them via the panels belowPass

All 4 checks passed. The chain says what it says.

Full verification report View on Basescan

Summary

Public thesis/export asset thesis_f114bfe88a0980bb. Evidence clusters in the synthesis pass target a prioritization gap: constrained candidates currently share ranking space with unconstrained linear peptides. We propose a discriminator for cyclization, disulfide, and high-proline handles separating these candidates from unconstrained linear peptides. Support is structural and assay-adjacent, including Structural metric for sequence GHQMQHHCDDSQPTDCWP and Cyclic Peptide Nanotubes in Deep Eutectic Solvents. Quality by Design-Based Formulation Development of an Oral Semaglutide Tablet constrains interpretation because formulation can shift peptide exposure. Runtime confidence is moderate, with low evidence strength; the §8 panel adjudicates whether separate validation is warranted. Boundary: public research artifact with explicit uncertainty, not biological validation.

Lineage

First-class on-chain edges. Every relation has a typed RelationType and a corresponding event log entry. Click any neighbor to navigate.

Ancestors (0)

No on-chain ancestors. This record is a root in the graph.

Descendants (0)

No on-chain descendants yet. This record is the most recent in its lineage.

Replay pointer

HTTPS replay artifact

The replay pointer references an external HTTPS URL. Fetch it and recompute the cited sha256 to verify.

https://www.protean.sh/export/ledger/replay/lane-balanced/manifest-1c475f8f05f8c524.json#sha256:1c2d29f761907e0bfc74d88db718025a22e1186868fa15c096eb2d9e198c582b

References

External identifiers cited by this record. Resolved via Crossref / arXiv at build time. The on-chain referencesDigest is 0xcc47…1324.

  • thesisthesis:thesis_f114bfe88a0980bb
  • sha256sha256:1c475f8f05f8c5246bf96f0c12d45fb86b5d7a1037dd6dbd309894f353deccba

Cite this record

Protean Labs. (1970, January 1). Scientific asset: Separating constrained from linear peptide candidates by conformational constraint handles (Scientific Record No. 0x57bb604c573629dabf9e252a3ae975eb3a09215c903ce8acb97985979fa6deec) [Ledger research record]. Protean Ledger, Base Mainnet. https://www.protean.sh/ledger/r/57bb604c

On-chain metadata

Record ID
0x57bb604c573629dabf9e252a3ae975eb3a09215c903ce8acb97985979fa6deec
Record type
ScientificAsset (12)
Lifecycle
Published (7)
Disclosure
Public (4)
Writer
0x074a…33de[Bankr automation wallet]
Registered (UTC)
—
Published (UTC)
Not yet published
Version
1
References digest
0xcc475088527e412830e9e40914183cdaeb5265d2771e4bc85f48cfdbb5b61324
Raw on-chain JSON ▾
{
  "recordId": "0x57bb604c573629dabf9e252a3ae975eb3a09215c903ce8acb97985979fa6deec",
  "priorObjectId": "0x0000000000000000000000000000000000000000000000000000000000000000",
  "recordType": "ScientificAsset",
  "recordTypeIndex": 12,
  "lifecycleState": "Published",
  "lifecycleStateIndex": 7,
  "disclosureState": "Public",
  "disclosureStateIndex": 4,
  "title": "Scientific asset: Separating constrained from linear peptide candidates by conformational constraint handles",
  "summary": "Public thesis/export asset thesis_f114bfe88a0980bb. Evidence clusters in the synthesis pass target a prioritization gap: constrained candidates currently share ranking space with unconstrained linear peptides. We propose a discriminator for cyclization, disulfide, and high-proline handles separating these candidates from unconstrained linear peptides. Support is structural and assay-adjacent, including Structural metric for sequence GHQMQHHCDDSQPTDCWP and Cyclic Peptide Nanotubes in Deep Eutectic Solvents. Quality by Design-Based Formulation Development of an Oral Semaglutide Tablet constrains interpretation because formulation can shift peptide exposure. Runtime confidence is moderate, with low evidence strength; the §8 panel adjudicates whether separate validation is warranted. Boundary: public research artifact with explicit uncertainty, not biological validation.",
  "author": "Protean Labs runtime",
  "runtimeId": "2026-06-03T05:20:06Z",
  "replayPointer": "https://www.protean.sh/export/ledger/replay/lane-balanced/manifest-1c475f8f05f8c524.json#sha256:1c2d29f761907e0bfc74d88db718025a22e1186868fa15c096eb2d9e198c582b",
  "publicationUrl": "https://www.protean.sh/research/thesis/thesis_f114bfe88a0980bb",
  "references": [
    "thesis:thesis_f114bfe88a0980bb",
    "sha256:1c475f8f05f8c5246bf96f0c12d45fb86b5d7a1037dd6dbd309894f353deccba"
  ],
  "referencesDigest": "0xcc475088527e412830e9e40914183cdaeb5265d2771e4bc85f48cfdbb5b61324",
  "supersedes": "0x0000000000000000000000000000000000000000000000000000000000000000",
  "retracts": "0x0000000000000000000000000000000000000000000000000000000000000000",
  "publishedAt": 0,
  "registeredAt": 0,
  "writer": "0x074abfb24d3fe2254672dc73f05c9696111033de",
  "version": 1,
  "registerBlock": 47889784,
  "registerTx": "d6c14fc9930372772d7e1bcbc0b39ae47dd6a29e53d04c42405c656c5215353c"
}
LedgerBase Mainnet · chainId 8453Schema protean.ledger.v1
Indexer digestsha256:1585c5…704b