Summary
Public thesis/export asset thesis_d6d68637d5edeec8. Evidence clusters from the synthesis pass targeted a prioritization gap between constrained peptides and unconstrained linear candidates. We propose a structural discriminator for cyclization, disulfide, and high-proline handles, separating validation paths before ranking. Support is sparse but convergent, including Structural metric for sequence GHQMQHHCDDSQPTDCWP and Cyclic Peptide Nanotubes in Deep Eutectic Solvents. Quality by Design-Based Formulation Development of an Oral Semaglutide Tablet and Protease-Resistant Azapeptide GLP-1 Analogue constrain structural-only triage. With evidence_strength 0.35 and uncertainty_score 0.33, we assign provisional confidence; the §8 panel adjudicates escalation versus standard linear-peptide validation. Boundary: public research artifact with explicit uncertainty, not biological validation.